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Genotoxicity

Genotoxicity

Genotoxicity refers to the destructive effects of mutagens such as high energy radiation and chemicals on cellular nucleic acids, particularly nuclear DNA. Single cell gel electrophoresis, or the comet assay, can be used to probe DNA fracture by mutagens and the g-H2AX immunofluorescence assay can used to quantify DNA double strand breaks. Each method has its challenges with respect to image analysis, but Gen5™ 3.0 has the ability to quantify either the %DNA in the comet tail or comet tail moment; or count g-H2AX foci to determine levels of genotoxicity.

 

Application Notes:

 

Related Webinars:

 

Visual Abstracts:

BioTek’s Visual Abstracts are brief animated presentations describing the Augmented Microscopy workflow of a specific application.

H2AX FOCI SPOT COUNTING AS A DETERMINATION OF GENOTOXICITY
γH2AX Foci Spot Counting as a Determination of Genotoxicity

Comet Assay: Single Cell Genotoxicity Measurement
Comet Assay: Single Cell Genotoxicity Measurement

 

 

Related Products:

 

Learn more about Genotoxicity applications - search our Application Notes and technical documentation in Resources.

 

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